Gwent Police received a report of a road traffic collision on Stow Park Crescent, at around 12.50pm on Friday 19 January.
Officers attended, along with personnel from the Welsh Ambulance Service and the Air Ambulance Service.
The collision involved one car – a silver Hyundai i20 – and a pedestrian.
The driver and pedestrian were taken to hospital for treatment. The pedestrian, an 83-year-old man from Newport, later died in hospital.
His next of kin have been informed and are being supported by specialist officers.
Officers investigating the collision want to speak to any residents, pedestrians or motorists who were in the area at the time of the collision.
Anyone with information, including dashcam or CCTV footage, is asked to contact police by calling 101, and quoting log reference 2400021884, or by sending a direct message on social media.
